静脉滴注消心痛对慢阻肺患者肺功能的即刻效应
Immediate effects of intravenous isosorbide dinitrate on lung function in COPD
池丽庄 1邹霞英 1邱小文1
作者信息
- 1. 广州军区广州总医院呼吸内科,中国,广州,510010
- 折叠
摘要
目的了解静脉滴注消心痛对慢性阻塞性肺疾病(COPD)患者肺通气及换气功能的影响.方法选择缓解COPD伴有阻塞性或混合性通气功能障碍的患者.静脉滴注消心痛前、后分别检测其动脉血压、心率(Hr)、血气,用力呼气肺活量(FVC)及流速容量曲线(FV),然后进行统计学处理及临床分析.结果用消心痛后,患者的FVC、一秒量(FEV1)、峰流速(FEFR)等通气指标均有显著增高;PaO2＞8.5 kpa组PaO2显著下降,平均下降(0.65±0.70)kpa,下降率为6.60%(P＜0.01);PaO2＜8.5 kpa组则无明显变化(P＞0.05).结论在COPD患者静脉滴注消心痛能缓解支气管痉挛,产生支气管扩张效应;对低氧血症患者不会使低氧血症恶化.
Abstract
Objects To study effects of intravenous isosorbide dinitrate(ISDN) on pulmonary ventilation and gas exchange in patients with chronic obstructive pulmonary disease(COPD). Methods Patients with obstructive or mixed hypoventilation secondary to COPD received intravenous infusion of 10 mg ISDN at the rate of 0. 11～0. 17 mg/min.Blood pressure,heart rate,arterial blood gases,forced vital capacity(FVC) and flow-volume(FV) were measured before and after medication. Clinical and statistical analyses were made. Results There were significant increases in FVC( P ＜0.01) ,FEV1 ( P ＜0.05) and PEFR( P ＜0.05) ;there was significant decreases in PaO2 in the group with PaO2≥8.5kpa( P ＜0.01), but there was little change in the group with PaO2 ＜8.5 kpa( P ＞0.05). Conclusion ISDN can relieve bronchospasm in COPD, causing bronchodilation. No exacerbation of hypoxemia was observed after ISDN in patients with hypoxemia.
关键词
消心痛/慢性阻塞性肺疾病/肺功能Key words
isosorbide dinitrate(ISDN)/pulmonary function/immediate effects引用本文复制引用
出版年
2004
NETL
NSTL
维普
万方数据