Objective To explore the diagnosis and treatment of Sjogren's syndrome in military pilots and the principles of aeromedical assessment.Methods The conclusions of clinical diagnosis and treatment and aeromedical assessment were analyzed by reporting the clinical data of a pilot with Sjogren's syndrome and reviewing the relevant literatures.Results This pilot with Sjogren's syndrome was admitted to the Medical Evaluation Department of Air Force Medical Center because of the physical examination for transformation,and there was no complaint of discomfort.Assay anti-nuclear antibody spectrum:anti-Ro-52 was positive.When the medical history was questioned,he complained of occasional dry eyes,so he underwent dry eye examination.The mean tear film rupture time was 10.24 s in the right eye and 7.38 s in the left eye.Lacrimal river height was 0.22 mm in the right eye and 0.15 mm in the left eye.Xerophthalmia was diagnosed.Salivary gland dynamic imaging examination indicated that the uptake and excretion functions of bilateral parotid glands were significantly reduced,which was consistent with Sjogren's syndrome and confirmed as Sjogren's syndrome.Through a comprehensive systematic examination,no damage to other organs was detected.Because of the current symptoms were mild and had no obvious impact on flight,the pilot was qualified for flight.Symptomatic treatment and regular hospital check-ups applied to monitor the changes of the disease.Conclusions The early symptoms of Sjogren's syndrome are mild and easy to be missed,so it is necessary to improve the awareness of the disease.Aeromedical assessment should be carried out according to the severity of the disease,the therapeutic effect,the aircraft types,the post of flight and the flight experience.