摘要
目的 系统评价肺移植患者衰弱的影响因素.方法 计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Web of Science、Embase、Elsevier ScienceDirect、CINAHL数据库中关于肺移植患者衰弱影响因素的研究.检索时限为建库至2023年11月.由2名研究者独立进行文献筛选、质量评价和数据提取,采用Stata 17.0软件进行Meta分析.结果 共纳入10篇研究,包括1 999例患者,提取13种影响因素,包括年龄(OR=1.05)、性别(OR=2.50)、体重指数(OR=0.38)、原发肺部疾病诊断(OR=2.90)、6 min步行距离(OR=0.34)、肺源分配评分(OR=0.69)、用力肺活量(OR=0.60)、移植前衰弱(OR=0.81)、低蛋白血症(OR=4.12)、血红蛋白(OR=0.50)、贫血(OR=4.37)、ICU入住时间(OR=1.24)、总住院时间(OR=1.05).使用简易体能状况量表作为肺移植患者衰弱评估工具,移植前衰弱发生率为24％,移植后衰弱发生率为50％.使用Fried衰弱表型作为肺移植患者衰弱评估工具,移植前衰弱发生率为30％.结论 影响肺移植患者衰弱的因素较多,护理人员应动态评估肺移植患者的衰弱程度,结合多学科协作模式,给予个体化、精准化的干预措施,改善或延缓衰弱进展.
Abstract
Objective To identify the factors associated with frailty in lung transplant patients by a meta-analysis.Methods Computerized search was performed for studies on the influencing factors of frailty in lung transplant patients in the CNKI,WanFangData,VIP,CBM,PubMed,Web of Science,Embase,Elsevier ScienceDirect and CINAHL databases.The search was conducted from the time of database construction to November 2023.Literature screening,quality assessment,and data extraction were performed independently by 2 investigators,and Meta-analysis was performed using Stata 17.0 software.Results 10 cohort studies,including 1 999 patients,were finally included,and 13 influencing factors were extracted,including advanced age(OR=1.05),female(OR=2.50),BMI(OR=0.38),diagnosis of primary pulmonary disease(OR=2.90),6MWD(OR=0.34),and lung allocation score(OR=0.69),FVC(OR=0.60),pre-transplant frailty(OR=0.81),hypoproteinemia(OR=4.12),hemoglobin(OR=0.50),anemia(OR=4.37),length of ICU stay(OR=1.24),and total length of stay(OR=1.05).Short Physical Performance Battery is an assessment tool for frailty in lung transplant patients,with an incidence of frailty in 24％before transplantation and 50％in post-transplantation.Fried Frailty Phenotype is an assessment tool for frailty in lung transplant patients,with a pre-transplant frailty incidence of 30％.Conclusion There are many factors involved in the incidence of frailty in lung transplant patients,and nursing staff should dynamically evaluate the frailty of lung transplant patients,and give individualized and precise interventions in combination with a multidisciplinary model to improve or delay the progression of frailty.
维普
万方数据