摘要
目的 探讨糖类抗原125(CA12-5)、糖类抗原199(CA19-9)联合癌胚抗原(CEA)在子宫内膜癌患者中的诊断价值.方法 选择2022年1-12月本院收治的子宫内膜癌患者48例为观察组;选择同期健康体检者127例为对照组.采用MAGLUMI X8化学发光分析仪测定CA12-5、CA19-9及CEA水平,比较两组CA12-5、CA19-9及CEA水平,分析不同性别、年龄受试者人群肿瘤标志物水平;绘制ROC曲线,分析CA12-5、CA19-9、CEA及三者联合在子宫内膜癌中的诊断效能.结果 48例子宫内膜癌患者均经病理检查确诊;且观察组肿瘤标志物CA12-5、CA19-9及CEA水平高于对照组健康体检者(P<0.05);不同年龄人群患者CA19-9及CEA阳性率,差异有统计学意义(P<0.05);ROC曲线结果表明:肿瘤标志物CA12-5、CA19-9及CEA联合检测在子宫内膜癌诊断灵敏度高于单一指标(P<0.05);特异度低于单一指标(P<0.05).结论 肿瘤标志物CA12-5、CA19-9及CEA在子宫内膜癌中呈高表达,且不同年龄人群存在差异性,不同肿瘤标志物联合测定可获得较高的诊断效能.
Abstract
Objective To explore diagnostic value of carbohydrate antigen 125(CA12-5),carbohydrate antigen 199(CA19-9)combined with carcinoembryonic antigen(CEA)for patients with endometrial cancer.Methods The paper chose 48 patients with endometrial cancer in our hospital from January 2022 to December 2022 as observation group;127 healthy individuals with physical examination during the same period as control group.Levels of CA12-5,CA19-9,and CEA were measured with MAGLUMI X8 chemiluminescence analyzer.Levels of CA12-5,CA19-9,and CEA were compared between two groups,levels of tumor markers in subjects of different genders and ages were analyzed.Diagnostic effect of CA12-5,CA19-9,CEA,and combination in endometrial cancer was analyzed by drawing ROC curves.Results All 48 patients with endometrial cancer were diagnosed with pathological examination,levels of tumor markers CA12-5,CA19-9,and CEA in observation group were higher than control group(P<0.05).There was statistical difference in positive rates of CA19-9 and CEA among patients of different age groups(P<0.05).ROC curve results indicated combined detection of tumor markers CA12-5,CA19-9,and CEA had higher sensitivity in diagnosis of endometrial cancer than single indicator(P<0.05),specificity was lower than single indicator(P<0.05).Conclusion Tumor markers CA12-5,CA19-9,and CEA are highly expressed in endometrial cancer,with difference among different age groups.Combined detection of different tumor markers can achieve high diagnostic Effect.
维普
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