Value of Tumor Marker Combined Test in Diagnosis of Primary Liver Cancer
Objective To analyze the diagnostic value of combined serum alpha-fetoprotein(AFP),cancer antigen 125(CA12-5)and carcinoembryonic antigen(CEA)tumor markers in the diagnosis of primary liver cancer.Methods A total of 60 patients with primary liver cancer treated in our hospital from January 2022 to March 2023 were selected to detect serum AFP,CA12-5 and CEA indexes,and the diagnostic results and diagnostic efficacy of single detection and combined detection were analyzed using surgical pathologic examination as the gold standard.Results The diagnosis results were analyzed,36 cases were positive and 24 cases were negative by surgical pathological examination.AFP detection confirmed 27 positive cases and 18 negative cases;There were 19 positive cases and 20 negative cases confirmed by CA12-5 test,18 positive cases and 17 negative cases confirmed by CEA test,34 positive cases and 17 negative cases confirmed by three combined tests.The sensitivity(94.44%)and accuracy(85.00%)of combined detection of AFP,CA12-5 and CEA in serum were higher than that of single detection,and the missed detection rate of AFP,CA12-5 and CEA in serum was(5.56%)lower than that of single detection,the difference was significant(P<0.05).There was no significant difference in specificity and misdiagnosis rate between combined detection and single detection(P>0.05).Conclusion In the diagnosis of primary liver cancer patients,the combined detection of AFP,CA12-5 and CEA tumor markers has ideal diagnostic value,which can improve sensitivity and accuracy,and reduce the rate of missed diagnosis.Therefore,it can be used as one of the effective diagnostic methods,worthy of promotion and popularization.
Tumor markersCombined detectionPrimary liver cancer
万方数据
维普
