首页|去甲基化药物联合CAG方案对老年白血病或难治复发性白血病疗效分析

去甲基化药物联合CAG方案对老年白血病或难治复发性白血病疗效分析

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目的 分析去甲基化药物与CAG方案治疗对于老年白血病患者以及复发性、难治白血病的治疗疗效。方法 选取2015年1月—2021年1月本院收治的白血病患者80例展开研究,依据对患者治疗方法之间的差异分为对照组(40例)和观察组(40例),分别采取常规治疗、去甲基化药物联合CAG方案,比较在不同干预措施应用下的治疗效果、不良反应发生率、VEGF水平、bHGF水平、6个月存活率、生活质量。结果 分析两组患者的治疗效果,观察组高于对照组(P<0。05)。不良反应发生情况:观察组低于对照组(P<0。05)。治疗前,两组VEGF、bHGF水平对比差异无统计学意义(P>0。05);治疗后,观察组患者的VEGF以及bHGF水平均优于对照组(P<0。05)。生活质量对比:观察组评分更高(P<0。05)。6个月存活率:观察组患者存活率更长(P<0。05)。结论 在白血病患者护理期间,通过予以去甲基化药物联合CAG方案,在改善临床症状的同时有助于降低不良反应发生率,且6个月存活率明显提升,患者生活质量随之升高,很大程度上提高了治疗水平,在临床中值得应用和推广。
Curative Effect Analysis of Demethylated Drugs Combined with CAG Scheme on Elderly Leukemia Or Refractory Relapsed Leukemia
Objective To analyze curative effect of demethylating drugs and CAG scheme on elderly leukemia patients and relapsed and refractory leukemia.Methods The paper chose 80 leukemia patients admitted to our hospital from January 2015 to January 2021,and divided them into control group(40 cases)and observation group(40 cases)respectively based on difference of treatment methods,treated with routine treatment and combination of demethylated drugs and CAG scheme.Curative effect,incidence of adverse reactions,VEGF and bHGF levels,6-month survival rate,life quality were compared under different intervention measures.Results Curative effect in observation group was higher than control group(P<0.05).Adverse reaction incidence in observation group showed a downward trend(P<0.05).Before treatment,there was no statistically significant difference in VEGF and bHGF levels between two groups(P>0.05).After treatment,average levels of VEGF and bHGF in observation group were better than control group(P<0.05).Comparison showed,life quality scoresd in observation group were higher(P<0.05).6-month survival rate in observation group was higher(P<0.05).Conclusion During nursing period of leukemia patients,combination of demethylated drugs and CAG scheme can improve clinical symptoms,reduce incidence of adverse reactions,improve 6-month survival rate,life quality and treatment level significantly,which is worthy of application and promotion in clinical practice.

Demethylating drugsCAG schemeRefractory recurrent leukemiaCurative effectAdverse reactions

赵彩源、张如仙、张冰歌

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内蒙古巴彦淖尔市中医医院,内蒙古 巴彦淖尔 015000

去甲基化药物 CAG方案 难治复发性白血病 治疗效果 不良反应

2024

智慧健康

智慧健康

ISSN:
年,卷(期):2024.10(2)
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