Effect of Frailty on Prognosis of Elderly Patients with Transient Ischemic Attacks
Objective To explore effect of frailty on 2-year follow-up prognosis of elderly patients with transient ischemic attack(TIA),and analyze relevant factors of prognosis.Methods The paper continuously included elderly TIA patients in our hospital from January 2018 to December 2022 with longitudinal cohort study.Based on condition of concomitant frailty,the paper divided patients admitted during the same period,matched with age and medical history in a 1:1:1 ratio into pre frailty group and frailty group,with 132 cases in each group.in addition,it chose 132 patients without concomitant frailty during the same period as control group.Follow up was carried out continuously for 24 months for three groups,occurrence of cerebrovascular disease related events was main observation indicator,including new stroke,recurrent TIA,and all-cause mortality.Prognosis of patients was analyzed based on Kaplan Meier survival analysis and Log rank test,factors related to cerebrovascular events were analyzed based on regression model.Results Levels of hypersensitive C-reactive protein(hs CRP)in frail and pre frail groups were significantly higher than control group(P＜0.05).Median follow-up time was(22.4±2.3)months,with 68 cases(17.2%)of cerebrovascular events,including 15 cases(3.8%)of all-cause deaths,33 cases(8.3%)of recurrent TIA,and 20 cases(5.1%)of new stroke.Recurrence rates of TIA in frailty group,pre frailty group,and control group were 7.6%,4.5%,and 3.0%respectively,with P=0.027.Incidence rates of cerebrovascular events were 27.3%,15.2%,and 9.1%respectively,with P=0.016.Results based on multi factor Cox proportional hazards regression model showed,frailty(HR=2.114,95%CI:1.128～3.962,P=0.021)and pre frailty(HR=1.526,95%CI:1.042～2.235,P=0.030)were independent related factors for occurrence of cerebrovascular events.Conclusion Frailty can increase risks of recurrent TIA of TIA elderly patients significantly,which is an independent related factor of cerebrovascular events.
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