Expression and Clinical Analysis of HER2 in Bladder Urothelial Carcinoma
Objective To investigate expression and clinical analysis of HER2(human epidermal growth factor receptor 2)in bladder urothelial cell carcinoma disease and normal bladder mucosal tissue.Methods The paper chose 32 patients with bladder urothelial carcinoma diagnosed and treated in Taizhou City the Second People's Hospital from November 2021 to December 2022 as observation group,and 32 normal bladder mucosal tissue patients diagnosed and treated in the hospital during the same period as control group.Expression of HER2 protein was detected with immunohistochemistry,and positive detection rates were compared statistically.In addition,difference in positive rate of HER2 protein expression was compared by combining pathological grading,age distribution,tumor diameter and other information of observation group.Results According to statistical results,positive rate of HER2 protein expression in observation group was significantly higher than control group(P＜0.05).Further analysis showed positive rate of HER2 protein expression of high-grade patients with pathological grading was significantly higher than low-grade patients(P＜0.05),there was no statistically significant difference in positive rate of HER2 protein expression among patients of different ages(P＞0.05).In addition,positive rate of HER2 protein expression of patients with tumor diameter exceeding 2.0cm was significantly higher than patients with tumor diameter less than 2.0cm(P＜0.05).Conclusion Positive rate teat of HER2 protein expression can diagnose bladder urothelial carcinoma,pathological grading and tumor diameter have direct effect on HER2 expression of patients,which provides reliable basis for clinical practice and is worthy of application and promotion.
万方数据
维普
