Clinical Value of Neoadjuvant Chemotherapy Combined with Synchronous Radiotherapy and Chemotherapy in Treatment of Advanced Cervical Cancer
Objective To analyze effect of neoadjuvant chemotherapy combined with synchronous radiotherapy and chemotherapy in treatment of advanced cervical cancer.Methods The paper chose 80 patients with advanced cervical cancer in the hospital from January 2021 to January 2023 as study subjects,and divided them into two groups with random number table method.Control group was treated with synchronous radiotherapy and chemotherapy,while observation group with neoadjuvant chemotherapy.Curative effect was compared.Results Total response rate in observation group was 97.50%after treatment with different schemes,significantly higher than 85.00%in control group(P<0.05).Before treatment,there was no difference in levels of T cell subsets between two groups.After treatment,levels of CD3+and CD4+in observation group were higher than control group,levels of CD8+were lower than control group,with statistical significance(P<0.05).During treatment period,small number of patients experienced bone marrow suppression,hematological toxicity reactions,and gastrointestinal reactions.Total incidence rate in observation group was 15.00%,not significantly different from 10.00%in control group(P>0.05).Total scores of life quality in observation group was(78.24±2.16)points,higher than(68.25±2.35)points in control group,scores of all indicators in observation group were higher,with statistical significance(P<0.05).Conclusion During treatment of advanced cervical cancer patients,neoadjuvant chemotherapy on the basis of synchronous radiotherapy and chemotherapy can enhance curative effect further,with significant advantages in regulating T cell subsets,withotu increasing risks of adverse reactions,which is safe and feasible.
Neoadjuvant chemotherapySynchronous radiotherapy and chemotherapyMid to late stage cervical cancer
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