Retrospective Analysis of the Effects of Different Doses of Sodium Zirconium Cyclosilicate on Hyperkalemia in Maintenance Hemodialysis(MHD)Patients
Objective To retrospectively analyze the effect of different doses of sodium zirconium cyclosilicate on hyperkalemia in maintenance hemodialysis(MHD)patients.Methods 120 patients with hyperkalemia on hemodialysis from December 2020 to September 2022 in our hospital were retrospectively analyzed.Treatment methods:The study group was treated with 10 g tid of sodium zirconium silicate,and the control group was treated with placebo.During the maintenance period,according to the different dosage of sodium zirconium cyclosilicate,it was divided into three dose groups,which were 5g,10 g,15 g.d-1,respectively,and the control group was set to receive placebo intervention.The degree of reduction of serum potassium concentration during correction(within 48 hours),the number of cases with normal serum potassium concentration during maintenance,the total incidence of adverse events,and the incidence of edema were compared.Results This study showed that after the use of drugs during the correction period,the blood potassium level of the study group was significantly decreased compared with the control group(P<0.05).In the maintenance period,the proportion of patients who maintained the normal blood potassium level was higher in the three dose groups of 5,10,15g.d-1,and was higher than that of the control group(P>0.05).There was no statistical significance in the incidence of total adverse events between the 5,10g.d-1 and control groups(P>0.05),and the incidence of adverse events in 15 g.d-1 group was higher than that in control group(P<0.05).There was no significant difference in the incidence of edema in 5g.d-1 group compared with the control group(P>0.05),and the incidence of edema in 10 g.d-1 group and 15g.d-1 group was significantly higher than that in the control group(P<0.05).Conclusion In the correction stage and maintenance stage,the application of sodium zirconium cyclosilicate has a good effect on reducing potassium,but the adverse reactions and edema of sodium zirconium cyclosilicate in the maintenance stage of 15 g.d-1 are significantly increased,which is worthy of clinical attention.
Different dosagesSodium zirconium cyclosilicateHemodialysisHyperkalemia
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维普
