Relationship Study Between Cognitive Dysfunction and Autonomic Neuropathy of Type 2 Diabetes Patients
Objective To investigate correlation between cognitive dysfunction and autonomic neuropathy of type 2 diabetes patients.Methods The paper chose 120 patients with type 2 diabetes mellitus(T2MD)in our hospital from January 2022 to December 2022 as study subjects,and divided them into groups according to condition of cardiovascular autonomic neuropathy(CAN).Control group(n=70)had no CAN,and observation group(n=50)had CAN.Results of MMSE and MoCA scales and COMPASS-31 scale were compared between two groups.Patients were grouped according to cognitive dysfunction condition.Group A(n=82)had no cognitive dysfunction,group B(n=38)had cognitive impairment,Various blood biochemical indicators were compared.Results MMSE scores and MoCA scores of observation group were lower than control group(P<0.05).COMPASS-31 scores of direct intolerance,vasoconstriction,secretion activity,gastrointestinal tract,bladder,and pupil movement in observation group were higher than control group(P<0.05).FBG,HbA1c,TC,TG,LDL-C,HDL-C,and fasting C-peptide levels in group B were comparable to group A(P>0.05),but after 2 hours of meals,C-peptide levels in group A were lower and CAN ratio was higher,(P<0.05).COMPASS-31 scores were negatively correlated with MMSE scores and MoCA scores(r=-0.176,-0.168,P<0.05).Conclusion There is significant correlation between cognitive dysfunction and CAN of T2MD patients,CAN can increase risk of cognitive dysfunction.
Type 2 diabetesCognitive impairmentAutonomic neuropathyCorrelation
万方数据
维普
