Analysis of Pathogen Distribution and Drug Sensitivity Results of Sputum Samples From 151 Elderly Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Chongming Area
Objective To clarify pathogen distribution and drug sensitivity of sputum samples of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in Chongming area,and optimize application of antibiotics in grassroots hospitals.Methods The paper chose 151 AECOPD patients admitted to our hospital from January 2020 to August 2022 as research subjects,collected demographic data,sputum samples for bacterial isolation,identification,and drug sensitivity testing.Results 151 strains were successfully isolated from sputum samples of patients,including 147 Gram negative bacteria(97.4%)and 4 Gram positive bacteria(2.6%).Main Gram negative bacteria,including Klebsiella pneumoniae(28.5%),Klebsiella pneumoniae subspecies(22.5%),Escherichia coLI(12.6%),and Pseudomonas aeruginosa(12.6%),have good sensitivity to common drugs,while genus Acinetobacter(4.6%)has high resistance.Gram positive bacteria have high sensitivity to common drugs.Conclusion Distribution of pathogens of elderly AECOPD patients in Chongming area is mainly Gram negative bacteria,especially Klebsiella pneumoniae and its subspecies,Escherichia coli,and Pseudomonas aeruginosa,with less occurrence of drug resistance.Therefore,it is recommended to choose appropriate pathogen β Initial treatment with lactamase inhibitors,cephalosporins,or fluoroquinolone antibiotics.
万方数据
维普
