首页|胶原蛋白与细胞焦亡的联系与研究进展

胶原蛋白与细胞焦亡的联系与研究进展

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胶原蛋白(Collagen)是人体中不可或缺的组成成分,主要存在于人体皮肤、筋膜、肌腱中,对维持组织的基本结构和功能至关重要。细胞焦亡(Pyroptosis)是一种复杂的细胞程序性死亡方式,在机体出现炎症时发挥重要的作用。近些年,有关细胞焦亡的研究已经获得了众多的进展,且成为目前最受瞩目的热点之一。胶原蛋白的研究已在细胞焦亡机制方面显示出巨大前景,相关研究表明,细胞焦亡的发生与体内胶原蛋白含量的变化发展密切相关。本文将从胶原蛋白的结构、细胞焦亡的机制通路、胶原蛋白对人体的作用、细胞焦亡对胶原蛋白的影响等方面进行综述,旨在为胶原蛋白与细胞焦亡的相关研究提供参考,为各种疾病的诊疗提供新的思路,这也可能成为将来治疗临床疾病的一个新的研究方向。
Relationship and Research Progress Between Collagen and Cell Apoptosis
Collagen is an essential component of human body,mainly exists in skin,fascia,and tendons,which is crucial for maintaining basic structure and function of tissues.Pyroptosis is a complex programmed cell death pathway with important role for inflammation in the body.Research on cell apoptosis has made significant progress and become one of the most attention grabbing hotspots in recent years.Study of collagen has shown great potential in mechanism of cell pyroptosis,related studies have shown occurrence of cell pyroptosis is closely related to changes and development of collagen content in the body.The article reviews structure of collagen,mechanism and pathway of cell pyroptosis,effect of collagen in human body,and effect of cell pyroptosis on collagen,to provide reference for related research of collagen and cell pyroptosis,and new ideas for diagnosis and treatment of various diseases,which may be a new research direction for future treatment of clinical diseases.

Collagen proteinCell pyroptosisFibrosisInflammation

董俊娟、都日娜、赵鹏伟、高耀星

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内蒙古医科大学,内蒙古 呼和浩特 010059

内蒙古自治区国际蒙医医院 皮肤科,内蒙古 呼和浩特 010050

胶原蛋白 细胞焦亡 纤维化 炎症

2024

智慧健康

智慧健康

ISSN:
年,卷(期):2024.10(7)
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