Distribution and Antibiotic Resistance Analysis of Pathogenic Bacteria of Bloodstream Infections in A Tertiary Hospital from 2017 to 2021
Objective To explore distribution and drug resistance rate of pathogenic bacteria of bloodstream infections at Qingyuan People's Hospital from 2017 to 2021,and provide reference for rational selection of antibiotics and control of bloodstream infections in clinical practice.Methods The paper carried out bacterial identification and drug sensitivity testing with VITEK2 and BD Phoenix M50 fully automatic bacterial identification and drug sensitivity analysis system,interpreted drug sensitivity results with 2020 CLSI standard,and analyzed data with WHONET 5.6 software.Results 3263 positive strains of bleeding culture were isolated,including 3238 bacterial strains(99.23%)and 25 fungal strains(0.77%).Detection rates of methicillin-resistant Staphylococcus aureus(MRSA)and methicillin-resistant coagulase negative Staphylococcus(MRCNS)were 26.0%and 67.2%respectively.No Staphylococcus aureus resistant to vancomycin or linezolid was detected.Sensitivity of Enterococcus faecalis to commonly used antibiotics was higher than Enterococcus faecalis,and a strain of Enterococcus faecalis resistant to vancomycin was found.Resistance rates of major Enterobacteriaceae bacteria to meropenem and imipenem were both below 10%.Resistance rates of Pseudomonas aeruginosa to two carbapenems in non fermenting Gram negative bacteria were both below 10%,while Acinetobacter baumannii was above 40%.Conclusion High detection rate of multidrug-resistant bacterial strains poses extremely serious challenges to clinical control of bloodstream infections.Therefore,it is necessary to grasp indications of antibiotics and guide clinical rational selection of antibiotics strictly.
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