首页|2型糖尿病肠道菌群与血糖、血脂等生化指标的相关性分析

2型糖尿病肠道菌群与血糖、血脂等生化指标的相关性分析

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目的 探讨2型糖尿病肠道菌群与血糖、血脂等生化指标的相关性分析。方法 将2020年1月—2022年12月在本院治疗的100例2型糖尿病患者作为观察组,将同期100例健康体检者作为对照组,对比两组的肠道菌群指标、血糖及血脂指标,分析两者的相关性。结果 观察组双歧杆菌、乳酸杆菌数目更低,而其他各项菌群数目高于对照组(P<0。05);观察组HDL-C水平更低,其他各项指标均更高(P<0。05);Pearson相关分析显示,血糖、血脂与拟杆菌、肠球菌、肠杆菌、酵母菌呈正相关,与双歧杆菌、乳酸杆菌呈负相关(P<0。05),而HDL-C则相反(P<0。05)。结论 2型糖尿病肠道菌群与血糖、血脂等生化指标存在明显相关性,两者互相影响,抑制2型糖尿病病情进展。
Correlation Analysis of Intestinal Microflora with Blood Glucose,Blood Lipid and Other Biochemical Indexes of Type 2 Diabetes
Objective To explore correlation between intestinal flora and biochemical indexes including blood glucose and blood lipid of type 2 diabetes.Methods The paper chose 100 patients with type 2 diabetes in our hospital from January 2020 to December 2022 as observation group,and 100 healthy people in the same period as control group.Intestinal flora indicators,blood glucose and blood lipid indicators were compared between two groups,correlation between them was analyzed.Results Nnumber of Bifidobacterium and Lactobacillus in observation group was lower,while number of other bacterial groups was higher than control group(P<0.05).HDL-C level in observation group was lower,and all other indicators were higher(P<0.05).Pearson correlation analysis showed blood glucose and blood lipids were positively correlated with Bacteroides,Enterococcus,Enterobacterium,and Yeast,while negatively correlated with Bifidobacterium and Lactobacillus(P<0.05),while HDL-C was the opposite(P<0.05).Conclusion Intestinal flora of type 2 diabetes has obvious correlation with biochemical indexes,including blood sugar and blood lipid,which affect each other to promote progress of type 2 diabetes.

Type 2 diabetesIntestinal microbiotaBlood sugarBlood lipidsCorrelation

黄沁、李娥、桂元、肖婷

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华中科技大学医院 内全科,湖北 武汉 430074

2型糖尿病 肠道菌群 血糖 血脂 相关性

华中科技大学自主创新研究基金

2017KFYXJJ148

2024

智慧健康

智慧健康

ISSN:
年,卷(期):2024.10(8)
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