Application of TPSA and FPSA Ratio in Differential Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia
Objective To observe value of serum prostate specific antigen(TPSA)and free pre prostate specific antigen(FPSA)in differential diagnosis of prostate cancer and benign prostatic hyperplasia.Methods The paper chose 35 patients with prostate cancer and 35 patients with benign prostatic hyperplasia in our hospital from January 2022 to December 2022,measured TPSA and FPSA levels with microzyme immunolabeling.Levels of TPSA and FPSA between groups were compared,and serum TPSA concentrations at different ages were statistically analyzed.Diagnostic accuracy of TPSA and FPSA levels in both groups were observed,diagnostic accuracy of BHP and PCa under different prostate volumes and PSAD diagnostic values was compared.Results(1)Comparison showed,TPSA levels and F/T values in prostate cancer group were higher than benign prostatic hyperplasia group,with statistical difference of P<0.05.Comparison of FPSA levels between two groups showed,those of prostate cancer group were higher than benign prostatic hyperplasia group,with P>0.05,there was no statistically significant difference.(2)TPSA levels aged 66-75 and over 75 in prostate cancer group were higher than benign prostatic hyperplasia group,with statistical difference of P<0.05.(3)Diagnostic accuracy of prostate cancer group was higher than benign prostatic hyperplasia group,with P>0.05,with no statistical difference.(4)Prostate volume<45mL,diagnostic accuracy of BPH was lower than PCa,P<0.05,with statistical difference.(5)PSAD<1.00 ng/mL·cm3,diagnostic accuracy of BPH was higher than PCa,P<0.05,with statistical difference.PSAD<1.50ng/mL·cm3,diagnostic accuracy of BPH was higher than PCa,P<0.05,with statistical difference.Conclusion TPSA levels increase for patients with prostate cancer and benign prostatic hyperplasia.To further improve the accuracy of clinical diagnosis,comprehensive analysis of TPSA levels and F/T values is crucial,which has significant application value.
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