Clinical Effect Analysis of Esomeprazole and Omeprazole in Treatment of Reflux Esophagitis
Objective To explore value of esomeprazole and omeprazole drugs for patients with reflux esophagitis in clinical practice.Methods The paper chose 58 patients with reflux esophagitis in the hospital from February 2020 to April 2023for study,and divided them into groups with coin toss method.Reference group(29 cases)was treated with omeprazole,and study group(29 cases)with esomeprazole.Total effective rate of medication,physiological indicators relief time(burning pain behind the sternum,belching and acid reflux,choking sensation during eating),MNA scores(mini nutritional status scale),VAS scores(visual analogue pain scale),inflammatory factor index scores CRP(C-reactive protein)and IL-6(interleukin-6)were compared between two groups.Results Comparison of clinical effect showed,statistical results of patients with reflux esophagitis in study group had significant better than reference group(P<0.05).Statistical results of patients with reflux esophagitis in study group were significant lower than reference group in relief time of burning pain behind the sternum,belching and acid reflux,and choking sensation during eating(P<0.05).Before treatment,statistical results of MNA scores and VAS scores showed no significant difference in the statistical results between two groups,(P>0.05).After treatment,statistical results of MNA scores and VAS scores showed significant difference between two groups,(P<0.05).Before treatment,there was no significant difference in statistical results between study group and reference group in terms of CRP and IL-6 levels(P>0.05).After treatment,statistical results of CRP and IL-6 levels in study group were significant lower than reference group,(P<0.05).Conclusion During clinical practice of patients with reflux esophagitis,rational use of esomeprazole can more significantly improve medication effect,shorten the relief time of physiological indicators,improve inflammatory level of patients than omeprazole,which has higher application value.
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