Study on Crataegi Fructus in attenuating hyperlipidemia based on network pharmacology and molecular docking technology
Based on network pharmacology and molecular docking technology,this study explored possible mechanism of Crataegi Fructus,a homologous food of medicine and food,in attenuating hyperlipidemia.Based ETCM,HIT and other databases and literature mining,the active components and corresponding potential targets of Crataegi Fructus were obtained.The potential targets of Crataegi Fructus to attenuate hyperlipidemia were analyzed for PPI protein interaction analysis and KEGG enrichment analysis.Finally,the active components were docked with the core targets.The result showed that the five key active components of Crataegi Fructus to attenuate hyperlipidemia were linoleic acid,linolenic acid,Crategolic acid,kaempferol and quercetin.The five core targets were AKT1,RXRA,EGFR,AR and RXRB,which may attenuate hyperlipidemia by acting on PPAR signaling pathway,thyroid hormone signaling pathway,AMPK signaling pathway,IL-17 signaling pathway and AGE-RAGE signaling pathway.The results of molecular docking showed that the core targets had binding activity with the key active components.The study preliminarily verified the efficacy and possible mechanism of Crataegi Fructus in attenuating hyperlipidemia,which provided a research direction for further exploring the mechanism of Crataegi Fructus in attenuating hyperlipidemia.At the same time,it also provided theoretical support for the development of lipid-lowering Crataegi Fructus functional food.
NETL
NSTL
万方数据
