吸入用乙酰半胱氨酸溶液联合磷酸奥司他韦治疗病毒性肺炎的临床效果探讨
Clinical Effect Exploration of Inhaled Acetylcysteine Solution Combined with Oseltamivir Phosphate in Treatment of Viral Pneumonia
邹松兵 1蓝冰1
作者信息
- 1. 南宁市第一人民医院 呼吸与危重症医学科二区,广西 南宁 530021
- 折叠
摘要
目的 探讨吸入用乙酰半胱氨酸溶液联合磷酸奥司他韦治疗病毒性肺炎的临床效果.方法 将2022年1-12月在本院治疗的86例病毒性肺炎患者随机分为两组,对照组单用磷酸奥司他韦治疗,在此基础上,观察组使用吸入用乙酰半胱氨酸溶液治疗,对比两组的临床疗效、症状消失时间、炎症因子、T淋巴细胞亚群.结果 治疗有效率组间对比结果显示,观察组更高,疗效更好(P<0.05);观察组症状消失时间以及治疗时间明显短于对照组(P<0.05);治疗后CRP、PCT、LY、IL-6水平等炎症指标对比显示,观察组均下降更多,水平更低(P<0.05);观察组治疗后CD3+、CD4+、CD4+/CD8+均高于对照组,CD8+低于对照组(P<0.05).结论 吸入用乙酰半胱氨酸溶液联合磷酸奥司他韦治疗病毒性肺炎的临床效果显著,能有效抑制炎症,调节免疫,加快病情缓解速度.
Abstract
Objective To explore clinical effect of inhaled acetylcysteine solution combined with oseltamivir phosphate in treatment of viral pneumonia.Methods The paper chose 86 patients with viral pneumonia in our hospital from January 2022 to December 2022,and divided them into two groups randomly.Control group was treated with oseltamivir phosphate only,while observation group with inhaled acetylcysteine solution.Clinical effect,symptom disappearance time,inflammatory factors,and T lymphocyte subsets were compared between two groups.Results Comparison of treatment effect showed observation group had higher and better curative effect(P<0.05).The disappearance time of symptoms and treatment time in observation group was significantly shorter than control group(P<0.05).After treatment,comparison of inflammatory indicators showed,CRP,PCT,LY,and IL-6 levels in observation group were lower,with greater decrease,(P<0.05).After treatment,the CD3+,CD4+,CD4+/CD8+levels in observation group were higher than control group,while CD8+levels were lower than control group(P<0.05).Conclusion Inhaling acetylcysteine solution combined with oseltamivir phosphate can achieve significantclinical effect in treatment of viral pneumonia,can inhibit inflammation,regulate immunity,and accelerate the speed of disease relief effectively.
关键词
病毒性肺炎/吸入用乙酰半胱氨酸溶液/磷酸奥司他韦/临床效果Key words
Viral pneumonia/Inhalation of acetylcysteine solution/Oseltamivir phosphate/Clinical effect引用本文复制引用
出版年
2024
NETL
NSTL
万方数据