Anesthesia Effect Comparison between Remazolam Besylate and Propofol in Laparoscopic Cholecystectomy and Effect on Hemodynamics of Patients
Objective To compare and analyze anesthetic effect of remazolam besylate and propofol in laparoscopic cholecystectomy and effect on hemodynamics of patients.Methods The paper chose 75 patients treated with laparoscopic cholecystectomy in Lianyungang City Donghai County People's Hospital from January 2022 to March 2023 as study subjects,and divided them into reference group(n=37)and observation group(n=38)with random number table method.Reference group was anesthetized with propofol,while observation group with remrazolam besylate.Anesthesia effect,hemodynamics,and adverse reactions were observed and compared between two groups.Results Onset time,awakening time,and directional force recovery time of anesthesia in observation group was significantly shorter than control group,difference was statistically significant between the groups(P<0.05).Heart rate(HR),mean arterial pressure(MAP),and blood oxygen saturation(SpO2)of reference group was significantly shorter at time T2 after disappearance of eyelash reflex than that before anesthesia induction(T1),while MAP of observation group was significantly lower,difference was statistically significant between the groups(P<0.05).MAP and SpO2 in observation group at time T2 was significantly higher than control group,difference was statistically significant between the groups(P<0.05).HR and SpO2 in observation group at 1 minute(T3)after the start of surgery was significantly higher than control group,difference was statistically significant between the groups(P<0.05).Heart rate of observation group at the end of surgery(T4)and wakefulness(T5)was higher than control group,difference was statistically significant between the groups(P<0.05).Incidence of adverse reactions during anesthesia in observation group was significantly lower than control group,difference was statistically significant between the groups(P<0.05).Conclusion During laparoscopic cholecystectomy,anesthesia effect of remazolam besylate is better than propofol,hemodynamics of patients is more stable during surgery,with lower incidence of adverse reactions,which is worthy of clinical reference and application.
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