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先天性白内障致病基因的研究进展

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先天性白内障具有一定的遗传特质,是目前世界上公认的导致儿童弱视与失明的主要疾病之一.人们的晶状体在分化成熟过程中受到很多基因调控,形成一个精密的调控网络,任何一个调控环节在分化的过程中发生异常,都可能会改变晶状体的透明性,致使白内障产生.本文旨在综述先天性白内障致病的相关基因,为进一步揭示遗传因素对晶状体代谢的密切影响提供参考.
Research Progress on Pathogenic Genes of Congenital Cataracts
Congenital cataract has some certain genetic characteristics,which currently is recognized as one of main diseases causing amblyopia and blindness of children worldwide.Lenses of human being are regulated by precise network composed of multiple genes during differentiation process.If any regulatory link is abnormal during differentiation process,it may change transparency of the lens,and cause occurrence of cataracts.The article reviews relevant genes of congenital cataract pathogenesis,to provide reference for further revealing close influence of genetic factors on lens metabolism.

Genetic researchCongenital cataractLens

肖茗渊

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惠州卫生职业技术学院,广东 惠州 516000

遗传学研究 先天性白内障 晶状体

惠州市医疗卫生领域科技计划项目

2023CZ010114

2024

智慧健康

智慧健康

ISSN:
年,卷(期):2024.10(10)