Curative Effect and Safety of Irinotecan Combined with Capecitabine in Treatment of Advanced Colorectal Cancer
Objective To study curative effect of irinotecan combined with capecitabine on patients with advanced colorectal cancer.Methods The paper chose 106 patients with advanced colorectal cancer in our hospital,and divided them into control group and experimental group randomly,with 53 cases in each group.Control group was treated with treatment with capecitabine and oxaliplatin,while experimental group with treatment with capecitabine and irinotecan.Difference in treatment effect and safety was observed between two groups.Results The incidence of complications in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in IFG-Ⅱ and TGF-α indicators between the two groups before treatment(P＞0.05).1 month and 6 months after treatment The IFG-Ⅱ and TGF-α indicators of the experimental group were lower than those of the control group,and the difference was statistically significant(P＜0.05).The median survival time,progression-free survival time,hospitalization time,and quality of life score of the experimental group were all higher than those of the control group.In the comparison group,the difference was statistically significant(P＜0.05).The total effective rate of treatment in the experimental group was higher than that in the comparison group,and the difference was statistically significant(P＜0.05).Conclusion Surgical treatment can achieve less significance for advanced colorectal cancer patients,and chemotherapy treatment is more effective.Combination of capecitabine and irinotecan treatment is more effective,with better safety,which is worthy of clinical attention.
万方数据
维普
