Objective To establish an ion chromatography(IC)method for determining phosphate binding capacity of sevelamer carbonate.Methods The paper chose Thermo Fisher AS11-HC ion chromatography column(250mm x 4mm),with eluent of 10mmol/L potassium hydroxide solution and conductivity detector,suppression current of 25mA,flow rate of 1.0mL/min,the column temperature of 25℃,and injection volume of 25μL.Results Linearity of phosphate ions in range of 0.10-0.18mmol/L was good(r=0.9999),determination of phosphate binding capacity of carbonated Sevelamer carbonate was 5.6mmol/g,with RSD of 0.8%.Conclusion The method is fast,accurate and reliable,which can be used for determination of phosphate binding capacity of sevelamer carbonate.
维普
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