Correlation Study Between Neonatal Hypoglycemia and Brain Vulnerability
Objective To explore correlation between neonatal hypoglycemia and brain vulnerability.Methods The paper reviewed and analyzed 90 newborns with hypoglycemia admitted to our hospital from June 2017 to February 2023,and divided them into brain injury group and non brain injury group based on whether they had brain injury.Among them,there were 31 cases in brain injury group and 59 cases in non brain injury group.Blood glucose levels,time of first occurrence of hypoglycemia,duration of hypoglycemia,and serum indicators of brain nerve injury specific enolase(NSE),myelin basic protein(MBP),glial fibrillary acidic protein(GFAP),and S100 protein(S100)were detected,correlation was analyzed between hypoglycemia and the aforementioned serum indicators.Results There was no significant difference in initial diagnosis time of hypoglycemia between two groups(P>0.05).Blood glucose level in non brain injury group was significantly higher thanbrain injury group,duration of hypoglycemia was significantly shorter than brain injury group(P<0.05).Levels of NSE,MBP,GFAP,and S100 in venous blood of newborns in brain injury group were significantly higher than non brain injury group(P<0.05).Pearson correlation analysis showed,neonatal hypoglycemia was positively correlated to serum NSE,MBP,GFAP,and S100(P<0.05).Conclusion Severity of neonatal hypoglycemia is positively correlated with brain vulnerability.
万方数据
维普
