Expression and Intervention Effect of Serum D-Dimer,C-Reactive Protein,and Lactate Dehydrogenase of Elderly Patients with Severe Traumatic Brain Injury
Expression and Intervention Effect of Serum D-Dimer,C-Reactive Protein,and Lactate Dehydrogenase of Elderly Patients with Severe Traumatic Brain Injury
Objective To investigate the expression and intervention effect of serum D-dimer,C-reactive protein and lactate dehydrogenase in elderly patients with severe craniocerebral injury.Methods Fifty patients with severe traumatic brain injury treated in the ICU of Puning People's Hospital from June 2022 to February 2024 were selected as the observation group,and 50 healthy subjects were selected as the control group during the same period.Serum D-dimer,C-reactive protein and lactate dehydrogenase were detected in two groups.The correlation between the concentration of serum C-reactive protein and plasma D-dimer and the severity of the disease was analyzed.Results The expression levels of serum D-dimer,C-reactive protein and lactate dehydrogenase in observation group were significantly higher than those in control group(P<0.05).The more serious the disease was in observation group,the higher the serum D-dimer,C-reactive protein and lactate dehydrogenase levels were(P<0.05).The levels of serum D-D,LDH and CRP in poor prognosis group were significantly higher than those in good prognosis group(P<0.05).ROC analysis results showed that the area under ROC curve of serum D-dimer for diagnosis of severe craniocerebral injury in the elderly was 0.722,C-reactive protein was 0.861,and lactate dehydrogenase was 0.826.Serum D-dimer,C-reactive protein and lactate dehydrogenase all had important diagnostic value for severe craniocerebral injury.Conclusion The expression of serum D-dimer,C-reactive protein and lactate dehydrogenase in elderly patients with severe craniocerebral injury has clinical value and can be used to evaluate the intervention effect.
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