Epidemiological Characteristics and Related Risk Factors Analysis of Mild Cognitive Impairment of PD with Prodromal Stage
Objective To observe epidemiological characteristics and related risk factors of mild cognitive impairment of Parkinson's disease(PD)with prodromal stage.Methods The paper chose and surveyed 2598 community elderly individuals aged 60 and above in our hospital as study subjects.49 patients with PD prodromal stage(pPD)were evaluated for cognitive function with the Montreal Cognitive Assessment Scale(MoCA).Based on evaluation results,patients were divided into two groups,one was pPD mild cognitive impairment(pPD-MCI),and the other was cognitive function normal(pPD-NC).General clinical data,anxiety scores(SAS),depression scores(SDS),rapid eye movement sleep behavioral disorders and cognitive function were compared between the groups.Independent factors affecting incidence of pPD-MCI were analyzed with multiple logistic regression analysis.Results 30 cases(61.22％)had mild cognitive impairment among 49 patients with pPD,pPD and pPD-MCI patients mainly concentrated at age group of 66 to 75.There was no statistically significant difference in age,gender,SDS scores and behavioral disorders during REM sleep,(P＞0.05).Comparison showed,SAS scores and UPDRS Ⅲ scores of patients with pPD-MCI were significantly higher than those with pPD-NC.Years of education of patients with pPD-MCI were significantly shorter than those with pPD-NC,(P＜0.05).MoCA scores of pPD-MCI patients were significantly lower than pPD-NC patients,and cognitive scores in areas of visual space and executive function,abstraction,and delayed recall were significantly lower than pPD-NC patients,(P＜0.05).There was no statistically significant difference in cognitive scores of orientation,attention,naming and language domains between groups,(P＞0.05).Multiple logistic regression analysis showed independent risk factor affecting incidence of pPD-MCI was years of education,(P＜0.05).Conclusion Patients with pPD aged 66 to 75 have higher risks of mild cognitive impairment,which can cause damage to multiple cognitive domains.Years of education is an independent factor of pPD-MCI,who may have anxiety and negative psychology,it is necessary to further strengthen early psychological health interventions of patients with pPD-MCI.
万方数据
维普
