Objective To explore and analyze application of HPV-23 typing,TCT combined with P16 expression detection in cervical lesion screening.Methods The paper chose 200 women participated in cervical cancer screening in our hospital from June 2022 to June 2023 as research subjects,and calculated diagnostic sensitivity and specificity of HPV-23 typing,TCT,P16 single detection,and combined detection based on gold standard of HPV-23 typing,TCT,and P16 expression were detected and pathological results.Results 33 cases were positive and 62 cases were negative based on HPV-23 typing;35 cases were positive and 72 cases were negative based on TCT;19 cases were positive and 115 cases were negative based on P16;48 cases were positive and 139 cases were negative based on combined detection.Diagnostic sensitivities of HPV-23 typing,TCT,P16 single detection,and combined detection were 62.26％,66.04％,35.85％,and 83.02％respectively,with specificity of 42.18％,48.98％,78.23％,and 89.80％respectively.Sensitivity and specificity of combined detection was the highest(P＜0.05).Conclusion HPV-23 typing and TCT combined with P16 expression detection can achieve high value in screening cervical lesions,which can be the preferred screening method.
关键词
人乳头瘤病毒-23分型/液基薄层细胞学检测/P16/宫颈病变/筛查
Key words
Human papillomavirus-23 typing/Liquid based thin-layer cytology detection/P16/Cervical lesions/Screening
维普
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