Objective Compound formula α-ketonic acid can regulate metabolic disorders of patients with chronic renal failure(CRF)through amino acid conversion,and may alleviate oxidative stress response and improve curative effect on the basis of hemodialysis(HD)and hemoperfusion(HP)treatment.Based on this,the article explored effect of compound α-ketonic acid combined with HD and HP in treatment of CRF patients.Methods The paper divided 103 CRF patients in our hospital from March 2018 to December 2020 into control group of 51 cases with computer grouping method,treated with HD combined with HP treatment,while observation group of 52 cases with compound α-ketone acid therapy on the basis of control group.Curative effect,oxidative stress response superoxide dismutase(SOD),glutathione peroxidase(GSH-px),malondialdehyde(MDA),and advanced oxidative protein products(AOPP)were observed between two groups.Results After treatment,total effective rate of observation group was higher than control group,and difference between two groups was statistically significant(P＜0.05).Levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH px)in observation group were higher than control group,while levels of malondialdehyde(MDA)and advanced oxidative protein products(AOPP)were lower than control group(P＜0.05).Difference between two groups was statistically significant(P＜0.05).Conclusion Compound α-ketonic acid combined with HD,HP can reduce oxidative stress levels and improve curative effect of CRF patients.
关键词
复方α-酮酸/血液透析/血液灌流/慢性肾衰竭
Key words
Compound formula α-ketone acid/Hemodialysis/Blood perfusion/Chronic renal failure
维普
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