Analysis of Adverse Reactions Reports of Fluoroquinolone Antibiotics for Tuberculosis Patients and Effect on Rational Drug Use
Objective To investigate adverse reactions of fluoroquinolone antibiotics for tuberculosis patients,report and analyze effect on rational drug use.Methods The paper chose 110 tuberculosis patients with adverse reactions after receiving fluoroquinolone antibiotics in the First Hospital of the city from January 2020 to December 2021 as study subjects,carried on statistics of clinical indicators of research subjects,identify types of adverse reactions,analyze key influencing factors for adverse reactions,and propose suggestions on rational drug use.Results Among 110 tuberculosis patients with adverse reactions,number of females was relatively less than males,group with age between 30 and 40 had high incidence,accounting for approximately 61.82％(68/110),with significant difference from other age groups,(P＜0.05).Incidence of combination therapy was relatively higher,administration channel was mostly intravenous injection.Frequency of fluoroquinolone antibiotics was as following:ofloxacin,ciprofloxacin,levofloxacin,norfloxacin,moxifloxacin,gatifloxacin,etc.Adverse reactions included multiple aspects including skin,nerves,digestion and blood.Conclusion It is necessary to fully understand contraindications and indications of the drugs,and combine specific conditions of patients to ensure correct combination therapy,rational drug use,and reduce incidence of adverse reactions when treating tuberculosis patients with fluoroquinolone antibiotics.
TuberculosisFluoroquinolone antibioticsAdverse reactionsRational drug useCurative effect
万方数据
维普
