Curative Effect of Tirofiban Combined with Butylphthalide for Acute Progressive Cerebral Infarction and Its Effect on Biochemical Indicators of Patients
Objective To explore application of tirofiban combined with butylphthalide in treatment of patients with acute progressive cerebral infarction.Methods The paper chose 40 patients with acute progressive cerebral infarction in our hospital from May 2022 to March 2023,and divided them into two groups randomly,with 20 cases in each group.Control group was treated with single drug of butylphthalide,and experimental group with tirofiban and butylphthalide.Treatment status and biochemical indicators were compared between two groups.Results After treatment,total effective rate in experimental group was slightly higher,difference was not statistically significant(P＞0.05).Experimental group had lower levels of vascular endothelial growth factor(VEGF),nitric oxide(NO),and heme oxygenase-1(HO-1),and higher levels of brain-derived neurotrophic factor(BDNF)and cognitive impairment scale(MMSE)scores than control group(P＜0.05).Conclusion Tirofiban combined with butylphthalide can improve treatment effect,improve biochemical indicators and cognitive function of patients with acute progressive cerebral infarction,which is safe,effective,and worthy of widespread clinical application.
万方数据
维普
