Clinical Characteristics and Prognosis Research of Triple Negative Breast Cancer Patients with Low HER-2 Expression
Objective To analyze clinical characteristics and prognosis of triple negative breast cancer patients with HER-2 low expression.Methods The paper chose 108 triple negative breast cancer patients from October 2020 to December 2022 as study objects,and divided them into negative group and low expression group according to difference of HER-2 low expression.Clinical characteristics,postoperative recurrence rate,metastasis rate and postoperative survival rate was compared between two groups.Results Incidence rate of lymph node metastasis,axillary lymph node dissection rate of low expression group with Ki-67 and T3 of T staging increased significantly,recurrence or metastasis rate 3 years after surgery increased significantly(P<0.05).Low expression of HER-2,lymph node metastasis,and T3 staging are direct risk factors for disease recurrence of patients 3 years after surgery(P<0.05).Disease-free survival rate in low expression group was significantly lower than negative group(P<0.05).Conclusion There is some certain difference between clinical characteristics of triple negative breast cancer patients with low HER-2 expression and those of routine patients.Low expression of HER-2,lymph node metastasis,and T3 of T staging are direct risk factors for disease recurrence of patients after surgery,which have no significant effect on postoperative survival rate.
HER-2 low expressionTriple negative breast cancerClinical featuresPrognosis
万方数据
维普
