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小儿早期地中海贫血筛查的意义

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目的 分析小儿早期地中海贫血筛查的意义。方法 选取2020年12月—2022年12月在本院出生的3962例新生儿为研究样本,均对其进行了地中海贫血筛查工作,统计筛查结果,整理对照入组新生儿半年期的回访结果。结果 共筛查出218例地中海贫血患儿,占比5。50%,其中β0地中海贫血145例,占比3。66%,β+地中海贫血69例,占比1。74%,其他类型4例,占比0。1%;地中海贫血患儿的发育迟缓、智力损伤、感染、病理黄疸、神经缺损、死亡发生率均显著高于正常新生儿,组间比较差异有统计学意义(P<0。05)。结论 对小儿群体实施地中海贫血筛查有助于尽快检出地中海贫血,对其实施针对性的治疗,以降低患儿出现不良结局的发生率,建议临床尽快开展针对全体新生儿的早期地中海贫血筛查。
Screening Significance of Early Thalassemia of Children
Objective To analyze value of early thalassemia screening for pediatric population.Methods The paper chose 3962 newborns in our hospital from December 2020 to December 2022 as study samples,with early thalassemia screening,and analyzed screening results statistically,organized follow-up results of control group of children over a six-month period.Results There were 218 children with thalassemia screened out from 3962 children,accounting for 5.50%,including 145 cases of β0 thalassemia,accounting for 3.66%,69 cases of β+thalassemia,accounting for 1.74%,and 4 cases of other types,accounting for 0.1%.Incidence of developmental delay,intellectual impairment,infection,pathological jaundice,neurological deficits,and death of thalassemia children was significantly higher than normal children,difference between groups was statistically significant(P<0.05).Conclusion Thalassemia screening for pediatric population can detect thalassemia as soon as possible,carry on targeted treatment,and reduce incidence of adverse outcomes of children.It is recommended to carry out early thalassemia screening for children as soon as possible during clinical practice.

ChildrenThalassemiaEarly screeningValue

谢雪锋、陈雅玲、夏沪露、曾丽芬

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深圳市第二人民医院,广东 深圳 518000

新生儿 地中海贫血 早期筛查 价值

2024

智慧健康

智慧健康

ISSN:
年,卷(期):2024.10(17)