Expression and Clinical Significance of Long Chain Noncoding RNA TUG1 and UCA1 in Colon Cancer Tissues
Objective To investigate expression and clinical significance of long chain non coding RNAs TUG1 and UCA1 in colon cancer tissues.Methods The paper chose and reviewed 80 colon cancer patients from May 2018 to May 2020 as study objects,detected expression of TUG1 and UCA1 with in situ hybridization and qRT PCR,and studied expression status,pathological characteristics,and prognosis of patients.Results Expression of UCA1 and TUG1 in colorectal cancer tissue was not significantly correlated with gender,age,and pathological conditions(P>0.05),but was highly correlated with tumor size,lymph node metastasis,disease differentiation,and staging(P<0.05).Patients with high expression of UCA1 and TUG1 had larger tumors,lymph node metastasis,higher differentiation,and TNM staging dominated by I/Ⅱ.80 patients were followed up for 36 months,with median survival time of 33.75 months and 16 deaths.Overall postoperative survival rate was 80.00%(64/80).Kaplan Meier survival analysis showed,12 cases died and 38 cases survived due to high expression of UCA1 and TUG1,with survival rate of 76.00%(38/50).4 cases died and 26 cases survived due to low expression of UCA1 and TUG1,with survival rate of 86.66%(26/30).Conclusion High and low expression of lncRNATUG1 and UCA1 in rectal cancer tissue has some certain effect on prognosis of patients.
Colon cancerLong chain non coding RNATUG1UCA1Expression situation
万方数据
维普
