Effect of Sufentanil Combined with Nalbuphine on Pain and Stress Response After Total Knee Replacement Surgery
Objective To analyze effect of sufentanil combined with nalbuphine on pain and stress response after total knee arthroplasty.Methods The paper chose 80 patients with unilateral total knee replacement surgery in our hospital from January 2021 to June 2022 as research subjects,and divided them into control group,low-dose group,medium dose group,and high-dose group according to different doses,with 20 cases in each group.Pain levels and stress response indicators of four groups at different times were compared.Results VAS scores of T1,T2,T3,T4,and T5 groups decreased sequentially after surgery.VAS scores of each time period in high-dose group were lower than medium dose group,while VAS scores of each time period in medium dose group were lower than low dose group.VAS scores of control group were the highest(P<0.05).There was no statistically significant difference in CRP,COR,CD4+,and CD8+levels among four groups before anesthesia(P>0.05).After 12 hours of surgery,CRP and COR increased in four groups,while CD4+and CD8+levels decreased.Moreover,CRP,COR,and CD8+levels in high-dose group were lower than other groups.CD4+levels in high-dose group were higher than other groups(P<0.05).Conclusion Nalbuphine 1.4mg/kg+sufentanil 1.0μG/kg can effectively reduce pain and improve stress response indicators of patients with total knee arthroplasty.
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