舒芬太尼联合纳布啡对全膝关节置换术后疼痛、应激反应的影响
Effect of Sufentanil Combined with Nalbuphine on Pain and Stress Response After Total Knee Replacement Surgery
邓海啸 1杨冬婵1
作者信息
- 1. 湛江市第二中医医院,广东 湛江 524200
- 折叠
摘要
目的 分析舒芬太尼联合纳布啡对全膝关节置换术后疼痛、应激反应的影响.方法 选取2021年1月—2022年6月在本院行单侧全膝关节置换手术的患者80例作为研究对象,按照舒芬太尼使用剂量的不同将其分为对照组、低剂量组(0.6mg/kg)、中剂量组(1.0mg/kg)和高剂量组(1.4mg/kg),每组20例.对比四组患者不同时间疼痛情况以及应激反应指标.结果 术后T1、T2、T3、T4和T5组VAS评分依次降低,其中高剂量组每个时间段VAS评分均低于中剂量组,中剂量组每个时间段VAS评分低于小剂量组,对照组VAS评分最高(P<0.05);麻醉前四组CRP、COR、CD4+、CD8+水平差异无统计学意义(P>0.05);术后12h四组CRP、COR均升高,CD4+、CD8+水平均降低,且高剂量组的CRP、COR以及CD8+均低于其他组;高剂量组CD4+水平高于其他组(P<0.05).结论 纳布啡1.4mg/kg+舒芬太尼1.0μg/kg可有效减少全膝关节置换术后患者疼痛,改善应激反应指标.
Abstract
Objective To analyze effect of sufentanil combined with nalbuphine on pain and stress response after total knee arthroplasty.Methods The paper chose 80 patients with unilateral total knee replacement surgery in our hospital from January 2021 to June 2022 as research subjects,and divided them into control group,low-dose group,medium dose group,and high-dose group according to different doses,with 20 cases in each group.Pain levels and stress response indicators of four groups at different times were compared.Results VAS scores of T1,T2,T3,T4,and T5 groups decreased sequentially after surgery.VAS scores of each time period in high-dose group were lower than medium dose group,while VAS scores of each time period in medium dose group were lower than low dose group.VAS scores of control group were the highest(P<0.05).There was no statistically significant difference in CRP,COR,CD4+,and CD8+levels among four groups before anesthesia(P>0.05).After 12 hours of surgery,CRP and COR increased in four groups,while CD4+and CD8+levels decreased.Moreover,CRP,COR,and CD8+levels in high-dose group were lower than other groups.CD4+levels in high-dose group were higher than other groups(P<0.05).Conclusion Nalbuphine 1.4mg/kg+sufentanil 1.0μG/kg can effectively reduce pain and improve stress response indicators of patients with total knee arthroplasty.
关键词
舒芬太尼/纳布啡/全膝关节置换术/疼痛/应激反应Key words
Sufentanil/Nalbuphine/Total knee replacement surgery/Pain/Stress response引用本文复制引用
基金项目
湛江市科技计划项目(2021B01088)
出版年
2024
NETL
NSTL
万方数据