Clinical Study on Perioperative Infusion of Different Doses of Dexmedetomidine for Prevention and Treatment of Postoperative Delirium and Cognitive Impairment of Elderly Patients with Elective Surgery
Objective To explore the application effect of perioperative dexmedetomidine (Dex) infusion in the prevention and treatment of postoperative delirium (POD) and postoperative cognitive impairment (POCD) of elderly patients with elective surgery. Methods The paper chose 80 elderly patients with elective surgery from April 2020 to April 2023 as study subjects,and divided them into the control group (40 cases) and study group (40 cases) with random number table method. The control group was treated with intravenous infusion of remifentanil,while study group with intravenous infusion of Dex. Difference in perioperative indicators,stress indicators cortisol (Cor),superoxide dismutase (SOD),aldosterone (ALD),POD,and POCD incidence was compared between two groups. Results After intervention,the study group had better recovery time,average length of stay,and postoperative perception of the disease than the control group (P<0.05). The levels of Cor and ALD of two groups at 12 hours after surgery were higher than those before surgery in the same group,while the level of SOD was lower than before surgery in the same group. However,the magnitude of level changes in the study group was lower than the control group (P<0.05). Incidence of POD and POCD in the study group was lower than the control group (P<0.05). Conclusion Dex infusion anesthesia can significantly improve perioperative related indicators,reduce stress reactions and respiratory depression,and lower risks of POD and POCD of elderly patients with elective surgery.
万方数据
维普
