Effect of Different Doses of Metformin on Glucose and Lipid Metabolism of Obese PCOS Patients Based on Hormone Therapy
Objective To investigate the effect of routine and high-dose metformin on glucose and lipid metabolism of obese polycystic ovary syndrome (PCOS) patients.Methods The paper chose 60 obese PCOS patients in our hospital from March 2021 to March 2023 as research subjects,and divided them into the observation group (n=30) and the control group (n=30) with random number table method.Both groups were treated with metformin based on routine hormone therapy,with the control group with daily dose of 1.5 g and the observation group with daily dose of 2.5 g.Glucose metabolism indicators fasting insulin (FINS),fasting blood glucose (FPG),2-hour postprandial blood glucose (2hPG),metabolic indicators total cholesterol (TC),triglycerides (TG),high-density lipoprotein cholesterol (HDL-C),and low-density lipoprotein cholesterol (LDL-C) levels,and adverse reactions after medication were compared between two groups.Results After 6 months of treatment,fasting insulin,fasting blood glucose,and 2-hour postprandial blood glucose levels in the observation group were lower than the control group (P<0.05).The observation group had lower levels of TC,TG,LDL-C,and body mass index (BIM),and higher HDL-C level than the control group (P<0.05).There was no statistically significant difference in adverse reactions between two groups after medication (P>0.05).Conclusion High-dose metformin can help improve glucose and lipid metabolism levels,create good rehabilitation conditions for obese PCOS patients without adverse drug reactions,which has high safety.
万方数据
维普
