Effect of Moxapride Combined with Esomeprazole Enteric-Coated Capsule in the Treatment of Chronic Atrophic Gastritis of the Elderly
Objective To observe the effect of Moxapride combined with esomeprazole enteric-coated capsule on chronic atrophic gastritis of the elderly,and provide some reference for rational drug use. Methods 80 elderly patients with chronic atrophic gastritis accompanied by Hp infection were selected as subjects,and divided into two groups with randomly fetching numbers based on data collection. Two groups were treated with basic support treatment,the control group (n=40) with esomeprazole enteric-coated capsule;and the observation group (n=40) with moxapride combined with esomeprazole enteric-coated capsule. Two groups of patients were treated with course of 4 weeks. Clinical effect was evaluated with software. Serum inflammatory cytokines (TNF-α,IL-8 and IL-6) were measured by venous blood before and after treatment. Results Clinical effect of the observation group was better than the control group,with statistical significance (P＜0.05). Compared with before treatment,serum inflammatory factor indexes (TNF-α,IL-8 and IL-6) decreased in 2 groups after 4 weeks of treatment (P＜0.05). Compared with the control group,the serum inflammatory factor indexes (TNF-α,IL-8 and IL-6) in the observation group were lower after 4 weeks of treatment (P＜0.05). Conclusion Moxapride combined with esomeprazole enteric-coated capsule can improve the effect of chronic atrophic gastritis of the elderly and reduce inflammatory factors,which is worthy of clinical promotion.
万方数据
维普
