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肝爽颗粒治疗慢性乙型肝炎及代偿期肝硬化效果观察

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目的 探究慢性乙型肝炎及代偿期肝硬化患者应用肝爽颗粒治疗的效果。方法 将南京市六合区人民医院2020年1月—2023年12月收治的80例慢性乙型肝炎及代偿期肝硬化患者纳入研究。应用Excel表格分组法分为研究组和一般组,每组40例。其中,一般组行常规治疗方案,研究组在常规治疗基础上加用肝爽颗粒治疗。比较两组治疗效果、肝功能、肝纤维化情况及不良反应发生情况。结果 研究组的治疗效果高于一般组(P<0。05);研究组肝功能中谷草转氨酶(GOT)、总胆红素(TBil)、谷丙转氨酶(GPT)、TBil及GPT水平均低于一般组(P<0。05);研究组肝纤维化情况中粘连蛋白(LN)、透明质酸酶(HA)及Ⅳ型胶原(Ⅳ-C)水平低于一般组(P<0。05);两组不良反应发生情况比较,差异无统计学意义(P>0。05)。结论 肝爽颗粒能够改善慢性乙型肝炎及代偿期肝硬化患者的治疗效果,改善肝功能,降低肝纤维化情况,安全性较好,值得推广。
Curative Effect Observation of Liver Refreshing Granules on Chronic Hepatitis B and Compensated Cirrhosis
Objective To explore curative effect of liver refreshing granules on patients with chronic hepatitis B and compensated cirrhosis. Methods The paper chose 80 patients with chronic hepatitis B and compensated cirrhosis in Nanjing City Luhe District People's Hospital from January 2020 to December 2023 for study,and divided the participants into the study group and the general group with Excel table grouping method,with 40 cases in each group. The general group was treated with routine treatment,while the study group with liver refreshing granules. Curative effect,liver function,liver fibrosis,and incidence of adverse reactions was compared between two groups. Results Curative effect of the study group was higher than the general group (P<0.05). Liver function levels of GOT,TBil,and GPT of the study group were lower than the general group (P<0.05). Liver fibrosis levels of LN,HA,and Ⅳ-C of the study group were lower than the general group (P<0.05). Comparison of adverse reactions between two groups showed P>0.05. Conclusion Liver refreshing granules can improve curative effect of patients with chronic hepatitis B and compensatory cirrhosis,enhance liver function,reduce liver fibrosis with good safety,which is worthy of promotion.

Liver refreshing granulesChronic hepatitis BCompensatory cirrhosisCurative effectLiver functionLiver fibrosis statusAdverse reaction conditions

陶立富

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南京市六合区人民医院感染科,江苏 南京 211500

肝爽颗粒 慢性乙型肝炎 代偿期肝硬化 治疗效果 肝功能 肝纤维化情况 不良反应情况

2024

智慧健康

智慧健康

ISSN:
年,卷(期):2024.10(29)