Analysis of osteoporosis-related biomarker levels in patients with subclinical hypothyroidism complicated with type 2 diabetes mellitus
Objective To investigate the levels of osteoporosis-related biomarkers in individuals with subclinical hypothyroidism complicated by type 2 diabetes mellitus.Methods A cross-sectional study.From January 2021 to June 2022,40 patients with subclinical hypothyroidism,40 patients with type 2 diabetes,40 patients with type 2 diabetes complicated with subclinical hypothyroidism,and 40 individuals receiving physical examination in Shanxi Bethune Hospital were selected as subjects in this study.The glucose and lipid metabolism indexes and bone metabolism indexes of the subjects were detected,and the differences and correlations of the metabolic indexes among the groups were analyzed by t-tests,nonparametric tests or correlation analysis.Results Compared with healthy group,beta C-terminal cross-linked telopeptides of type Ⅰ collagen(β-CTX)level in type 2 diabetes group was higher[(344.60±125.61)vs(227.56±68.33)pg/ml](t=-5.176,P＜0.001),osteocalcin(OC)and total procollagen type 1 aminoterminal peptide(t-PINP)were both lower[(15.76±4.70)vs(28.02±5.83)ng/ml,(43.49±13.63)vs(59.58±15.80)ng/ml](t=10.352,t=4.874,P＜0.001).The β-CTX level in type 2 diabetes patients complicated with hypothyroidism was higher than that in patients with simple subclinical hypothyroidism[(380.51±122.22)vs(212.41± 44.17)pg/ml](t=-8.180,P＜0.001),but the levels of OC and t-PINP were both lower[(13.67±4.06)vs(26.12±4.55)ng/ml,(38.76±9.53)vs(61.50±12.31)ng/ml](t=12.897,P＜0.001);but there was no significant difference in the three biomarkers between patients with type 2 diabetes mellitus complicated by subclinical hypothyroidism and those with type 2 diabetes mellitus alone.[β-CTX:(380.51±122.22)vs(344.60±125.61)pg/ml,OC:(13.67±4.06)vs(15.76±4.70)ng/ml,t-PINP:(38.76±9.53)vs(43.49±13.63)ng/ml](t=1.296,1.890,-1.799,all P＞0.05).In the patients with type 2 diabetes mellitus complicated by subclinical hypothyroidism,the β-CTX was positively correlated with fasting blood glucose(FBG)and glycosylated hemoglobin(HbA1c)(r=0.293,0.487,all P＜0.05),while OC and t-PINP were negatively correlated with FBG and HbA1c(r=-0.560,-0.502,-0.289,-0.326,P＜0.05).Conclusion Changes of serum osteoporosis-related biomarkers in subclinical hypothyroidism patients with type 2 diabetes indicate the increased risk of osteoporosis in those patients.
万方数据
维普
