Correlation between serum HbA1c,γ-GT,ICAM-1 levels and cognitive impairment in elderly patients with hyperlipidemia complicated with cardiovascular diseases
Objective To analyze the correlation between serum glycated hemoglobin(HbA1c),γ-glutamyltranspeptidase(γ-GT)and intercellular adhesion factor-1(ICAM-1)levels and cognitive impairment in elderly patients with hyperlipidemia complicated with cardiovascular disease.Methods In this retrospective cohort study,158 elderly patients who underwent examination and were diagnosed with hyperlipidemia complicated with cardiovascular disease at Beijing Anzhen Hospital Affiliated with Capital Medical University from January to December 2022 were selected as study subjects.The simple mental state scale(MMSE)was assessed in the subjects in combination with the subject's level of education.Illiteracy≤17 points,primary school≤20 points,middle school and above≤24 points were classified as cognitive impairment group(67 cases),the rest were were classified into the non-cognitive impairment group(91 cases);and another 50 healthy elderly people who received physical examination in the same period were selected as the control group.The blood samples in the three groups were extracted to measure serum HbA1c,γ-GT and ICAM-1.The correlation between HbA1c,γ-GT and ICAM-1 levels with cognitive impairment were analyzed.Results The serum levels of HbA1c,γ-GT and ICAM-1 in the cognitive impairment group were all significantly higher than those in the non-cognitive impairment group and the control group[5.41％±1.04％vs 4.82％±0.95％,4.39％±0.86％;(52.01±10.96)vs(41.28±9.23),(25.03±7.17)U/L;(336.61±85.36)vs(286.93±72.53),(143.52±64.20)g/ml],and the MMSE score was significantly lower[(20.19±2.85)vs(25.30±1.24),(27.14±1.56)points](all P＜0.05).Serum levels of HbA1c,γ-GT and ICAM-1 were all significantly negatively correlated with MMSE score(r=-0.512,-0.498,-0.563)(all P＜0.05).The areas under the receiver operating characteristic curves(AUCs)for serum HbA1c,y-GT,and ICAM-1 levels in the assessment of cognitive dysfunction were 0.657,0.816,and 0.691,respectively(all P＜0.05).The optimal cut-off values were 5.115％,47.65 U/L,and 304.58 g/ml,respectively.Conclusion Serum HbA1c,γ-GT and ICAM-1 levels in elderly patients with hyperlipidemia complicated with cardiovascular disease are negatively correlated with cognitive impairment,and have certain value for the evaluation and early diagnosis of cognitive impairment.
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