Alteration of static and dynamic fractional amplitude of low-frequency fluctuation in patients with methamphetamine dependence using resting-state functional magnetic resonance imaging
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目的 采用分数低频振荡振幅(fractional amplitude of low frequency fluctuation,fALFF)方法分析甲基苯丙胺(methamphtamine,MA)依赖患者与健康对照者大脑活动强度的差异,并使用支持向量机(support vector machines,SVM)建立MA依赖者与健康人群的分类模型.方法 选择2014年2月至2019年10月于宁波大学附属康宁医院接受戒毒治疗的46例男性MA依赖患者(MA依赖组),同期招募46名与之相匹配的男性健康志愿者(对照组).采集所有受试者静息态功能磁共振成像数据,运用静态 fALFF 和动态分数低频振荡振幅(dynamic fractional amplitude of low frequency fluctuation,d-fALFF)方法分析比较2组脑功能活动的差异.采用Pearson偏相关分析方法分析MA依赖组差异脑区fALFF、d-fALFF值与简明精神病评定量表(Brief Psychiatric Rating Scale,BPRS)总分、各项因子分、初次吸食年龄以及服用MA总剂量的相关性.2组差异脑区的fALFF图和d-fALFF图作为特征构建基于SVM的分类.结果 与对照组相比,MA依赖组fALFF增高的脑区主要位于伏隔核、尾状核、壳核、杏仁核(t=-5.21～-2.72,均P＜0.05);fALFF减低的脑区主要位于额上回、额中回、眶回、扣带回(t=3.59～5.00,均P＜0.05);d-fALFF减低的脑区主要位于额上回、额中回、眶回、扣带回(t=3.33～4.87,均P＜0.05).MA依赖组右侧伏隔核fALFF值与初次吸食年龄呈正相关(r=0.537,P＜0.001).MA依赖组异常fALFF及d-fALFF值与BPRS总分、各项因子分以及服用MA总剂量(去除离群值后)之间均不存在相关性.基于fALFF图和d-fALFF图SVM对于2组分类的准确率分别为90.33％±6.89％和71.56％±7.80％.结论 MA依赖患者静息态大脑低频振荡活动存在异常,提示前额叶皮质活性僵化、功能损伤、反奖赏系统功能增强,这可能是导致MA依赖行为并反复发作的原因之一.此外,fALFF图可能对区分MA依赖者和对照者有一定参考意义.
Objective To investigate the difference in brain activity intensity between methamphetamine(MA)dependent patients(MA group)and healthy controls(control group)using fractional amplitude of low-frequency fluctuation(fALFF),and to establish a classification model between these two groups using support vector machine(SVM).Methods From February 2014 to October 2019,a total of 46 male MA-dependent patients and 46 male healthy controls were recruited from the Affiliated Kangning Hospital of Ningbo University.The study collected resting-state functional magnetic resonance imaging(rs-fMRI)data and analyzed the differences in brain functional activity between the two groups.This analysis was conducted using both static and dynamic fractional amplitude of low-frequency fluctuations(d-fALFF).Additionally,the study examined the correlation between fALFF/d-fALFF values in specific brain regions and the total scores,as well as each factor score,of the Brief Psychiatric Rating Scale(BPRS).Furthermore,the relationship between fALFF/d-fALFF values and the age of first use and total dose of MA in the MA group was investigated.Finally,the fALFF map and d-fALFF map of brain regions with significant differences between groups were used as features for constructing classification.Results Compared to the healthy control group,those dependent on MA showed significantly increased fALFF mainly in the nucleus accumbens,caudate nucleus,thalamus,and amygdala nucleus(t=-5.21--2.72,all P＜0.05).The MA group exhibited decreased fALFF in the superior frontal gyrus,middle frontal gyrus,orbital gyrus,and cingulate gyrus(t=3.59-5.00,all P＜0.05).Most of the brain regions with decreased d-fALFF overlapped with those exhibiting decreased fALFF(t=3.33-4.87,all P＜0.05).The results of the correlation analysis showed that the fALFF value of the right nucleus accumbens was positively correlated with the age of first use of MA(r=0.537,P＜0.001).There is no significant relationship between the abnormal fALFF and d-fALFF values in the MA group and the total scores and each factor scores of BPRS,as well as the total dose of MA taken(after removing outliers).Based on fALFF and d-fALFF values,the SVM classifier achieved accuracies of90.33％±6.89％and 71.56％±7.80％,respectively.Conclusions There are significant abnormalities in the low-frequency fluctuation of the resting brain in patients dependent on MA.These abnormalities reflect the rigidity of prefrontal cortex activity,functional impairment,and dysfunction of the anti-reward system.These factors may be one of the causes for MA dependent behavior and repeated episodes.In addition,the fALFF values may be helpful for distinguishing MA dependent individuals from the control group.
MethamphetamineMagnetic resonance imagingFractional amplitude of low frequency fluctuationSupport vector machine
NETL
NSTL
万方数据
