Schizophrenia is a common,severe,and complex psychiatric disorder worldwide.Genetic factors account for around 80％of the etiology of schizophrenia,yet objective diagnostic biomarkers remain lacking.This article reports two cases of female monozygotic twins diagnosed with schizophrenia,exhibiting a balanced translocation between 22q11.2 and 4p15.3.Reviewing the literature,we analyze and discuss the correlation between chromosomal balanced translocation regions and the pathogenesis of mental disorders.This aims to encourage psychiatrists to consider new perspectives on the diagnosis of schizophrenia.
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