Stiff person syndrome(SPS)is a rare neuro-immune disorder characterized by exaggerated startle responses and muscle spasms in response to minor stimuli.SPS is often misdiagnosed as panic disorder or agoraphobia.This paper reported a case of a patient with SPS presenting symptoms similar to panic attack.The patient had been misdiagnosed as dystonia,anxiety disorder and panic attack.The patient was finally correctly diagnosed through multiple disciplinary team discussions.This study integrates a comprehensive understanding of symptomatology and patient-reported experiences with targeted neurological evaluations and supplementary diagnostic tools to improve the accuracy of etiological diagnoses.This study aims to enhance the ability of psychiatrists to recognize somatic diseases presenting with psychiatric symptoms and to improve clinical diagnostic and treatment levels.