Kleine-Levin syndrome(KLS)is a rare,recurrent-remitting sleep disorder characterized by periodic hypersomnia,hyperphagia,and hypersexuality,accompanied by cognitive dysfunction,perceptual disturbances,mood changes,or psychiatric abnormalities.Patients typically experience recurrent episodes,with hypersomnic periods lasting from several days to weeks.Most KLS patients exhibit normal functions during the intermission period,while early-onset KLS cases in adolescents are rare,often presenting with frequent episodes and complex symptoms,which can easily lead to misdiagnosis.Therefore,this case report analyzed the detailed medical history,laboratory findings,differential diagnosis,and treatment of a teenage patient with KLS,along with a review of the literature.This case aims to provide a deeper understanding of the complex symptoms and diagnostic challenges associated with early-onset KLS in adolescents.