Expert consensus on the artificial liver blood purification system in treatment of cytokine storm syndrome
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细胞因子风暴综合征（cytokine storm syndrome，CSS）是一种由感染、肿瘤和自身免疫性疾病等病因引起的免疫反应失控的临床综合征。患者主要表现为血浆中细胞因子水平明显升高，并出现发热、全身多个系统或脏器发生炎症反应及功能损害，甚至衰竭而死亡。人工肝血液净化系统治疗能清除炎症因子，减轻炎症反应对机体的损伤，其在重症H7N9、重型/危重型新型冠状病毒感染患者临床救治中具有重要应用价值。专家组在《人工肝血液净化系统应用于重型、危重型新型冠状病毒肺炎治疗的专家共识》基础上，结合现有临床应用经验及国内外研究进展，针对人工肝血液净化系统治疗CSS患者的基本原理、治疗适应证、相对禁忌证、治疗模式选择、监测指标及疗效评价等进行总结，制订了本专家共识，供临床医护人员参考。 Cytokine storm syndrome（CSS）is a clinical syndrome characterized by uncontrolled immune reaction caused by infection，tumor or autoimmune diseases. It is mainly manifested by significantly elevated plasma cytokines levels，leading to fever，inflammation and functional damage in multiple systems or organs，and even death due to organ failure. The artificial liver blood purification system can effectively remove inflammatory factors and alleviate the damage of inflammation in CSS. It has important clinical application value in the treatment of severe H7N9 and severe/critical COVID-19 patients. Based on the Expert consensus on the application of artificial liver blood purification system in the treatment of severe and critical COVID-19，combined with clinical experiences，and domestic and foreign research progress，this expert consensus summarizes the basic principles，indications for treatment，relative contraindications，selection of treatment modes，monitoring indicators，and evaluation of efficacy of artificial liver blood purification system in the treatment of CSS patients，to provide reference for clinical application.
Cytokine storm syndrome（CSS）is a clinical syndrome characterized by uncontrolled immune reaction caused by infection，tumor or autoimmune diseases. It is mainly manifested by significantly elevated plasma cytokines levels，leading to fever，inflammation and functional damage in multiple systems or organs，and even death due to organ failure. The artificial liver blood purification system can effectively remove inflammatory factors and alleviate the damage of inflammation in CSS. It has important clinical application value in the treatment of severe H7N9 and severe/critical COVID-19 patients. Based on the Expert consensus on the application of artificial liver blood purification system in the treatment of severe and critical COVID-19，combined with clinical experiences，and domestic and foreign research progress，this expert consensus summarizes the basic principles，indications for treatment，relative contraindications，selection of treatment modes，monitoring indicators，and evaluation of efficacy of artificial liver blood purification system in the treatment of CSS patients，to provide reference for clinical application.
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