摘要
肌少症是与增龄相关的肌肉质量减少和功能减退,其增加了摔倒、骨折、死亡及住院等风险,严重威胁老年人的健康.构建动物模型是开展肌少症发病机制、临床干预及治疗方案设计研究的基础.由于肌少症表型的复杂性,使得选择合适的造模方法、构建恰当的动物模型至关重要.本文综述了近年来肌少症动物模型造模方法的相关进展,为开展肌少症发病机制、预防、治疗等相关研究提供参考.
Abstract
Sarcopenia,the age-related loss of muscle mass and functions,increases the risk of falls,fractures,death,and hospitali-zation and poses a serious threat to the health of the elderly.The construction of animal models constitutes the basis for research in its pathogenesis,clinical intervention and treatment planning.Due to the complexity of the sarcopenia phenotype,it is crucial to select an optimal modeling method and construct a suitable animal model.In this article,we reviewed the progress in methodology in animal model construction for sarcopenia in recent years,providing reference for the research in the pathogenesis,prevention,and treatment of sarcopenia.
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