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老年糖尿病群体衰弱现状及其影响因素

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目的 分析老年糖尿病群体衰弱现状及其影响因素.方法 回顾性分析 2020 年 2 月至 2022 年 8 月安徽医科大学附属阜阳人民医院收治的 248 例老年糖尿病患者(糖尿病组)及同时段门诊收集的 120 名健康体检人群(对照组)的临床资料,采用FRAIL量表进行衰弱评估.根据FRAIL量表评分,将糖尿病组患者分为衰弱组(n=76)和非衰弱组(n=172).采用SPSS 22.0 统计软件进行数据分析.根据数据类型,分别采用方差分析、t检验或 χ2 检验进行组间比较.采用多因素logistic回归模型分析老年糖尿病群体衰弱发生的影响因素.结果 糖尿病衰弱组及非衰弱组患者FRAIL量表评分明显高于对照组,衰弱组患者FRAIL量表评分明显高于非衰弱组,差异有统计学意义(P<0.05).多因素logistic回归分析结果显示,年龄≥70 岁(OR=3.162,95%CI 1.451~5.784;P<0.001)、糖尿病病程≥10 年(OR=4.052,95%CI 1.895~8.463;P=0.038)、糖化血红蛋白(HbA1c)>8.5%(OR=3.205,95%CI 1.461~6.230;P=0.023)、空腹血糖(FBG)≥6.1 mmol/L(OR=2.154,95%CI 1.032~2.964;P=0.027)、营养风险(营养不良)(OR=3.451,95%CI 2.014~5.375;P=0.034)及肌少症(OR=2.845,95%CI 1.032~3.748;P<0.001)为老年糖尿病群体衰弱发生的危险因素.睡眠质量(良好)为老年糖尿病群体衰弱保护因素(OR= 0.851,95%CI 0.612~0.941;P=0.018).结论 老年糖尿病患者衰弱发生率较高,衰弱的发生与患者年龄、糖尿病病程、血糖水平及糖尿病并发症密切相关.临床需加强对这些患者的重视,及时采取针对性干预措施,以预防和延缓衰弱的发生与发展.
Current status of debilitation in elderly diabetic population and its influencing factors
Objective To analyze the current status of frailty in the elderly diabetic population and its influencing factors.Methods A retrospective study was conducted of the clinical data of 248 elderly diabetic patients(diabetes group)admitted to the Fuyang People's Hospital of Anhui Medical University from February 2020 to August 2022 and of 120 healthy individuals(control group)receiving physical examinations in outpatient clinic during the same period of time.Frailty assessment was performed using the FRAIL scale.Based on the FRAIL scores,the diabetic patients were divided into the frail group(n=76)and the non-frail group(n=172).SPSS statistics 22.0 was used for data analysis,and ANOVA,t test or Chi-square test were employed for intergroup comparisons,depending on the data type.Multivariate logistic regression analysis was conducted to identify the influencing factors of frailty in the elderly diabetic population.Results The FRAIL scores in both the frail and non-frail diabetic groups were significantly higher than those in the control group,and the frail group had significantly higher FRAIL scores than the non-frail group(P<0.05).Multivariate logistic regression analysis showed that age≥70 years(OR=3.162,95%CI 1.451-5.784;P<0.001),diabetes duration≥10 years(OR=4.052,95%CI 1.895-8.463;P=0.038),glycated hemoglobin A1c(HbA1c)>8.5%(OR=3.205,95%CI 1.461-6.230;P=0.023),fasting blood glucose(FBG)≥6.1 mmol/L(OR=2.154,95%CI 1.032-2.964;P=0.027),nutritional risk(malnutrition)(OR=3.451,95%CI 2.014-5.375;P=0.034)and sarcopenia(OR=2.845,95%CI 1.032-3.748;P<0.001)were identified as the risk factors of frailty,and that good sleep quality(OR=0.851,95%CI 0.612-0.941;P=0.018)as a protective factor against frailty in the elderly diabetic population.Conclusion The prevalence of frailty is high in the elderly diabetic patients,and its occurrence is closely associated with age,diabetes duration,blood glucose level and diabetic complications.Clinical practitioners should pay attention to these patients and take timely targeted interventions to prevent and delay the occurrence and development of frailty.

ageddiabetes mellitusfrailty

高婷婷、陈天娇、时诗柔

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安徽医科大学附属阜阳人民医院内分泌科,安徽 阜阳 236000

老年人 糖尿病 衰弱现状

安徽省卫生健康委科研项目

AHWJ2021B111

2024

中华老年多器官疾病杂志
中国人民解放军总医院老年心血管病研究所

中华老年多器官疾病杂志

CSTPCD
影响因子:0.728
ISSN:1671-5403
年,卷(期):2024.23(2)
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