摘要
目的 探讨新疆维吾尔自治区前列腺癌患者根治术后生活质量变化情况及其影响因素.方法 回顾性分析2021年1月至2022年12月新疆维吾尔自治区人民医院进行根治术治疗的240例前列腺癌患者的临床资料,根据生活质量得分将其分为生活质量良好组(n=85)与生活质量欠佳组(n=155).采用SPSS 20.0统计软件进行数据处理.根据数据类型,分别采用t检验或x2检验进行组间比较.采用logistic回归分析前列腺癌根治术患者生活质量的影响因素.结果 治疗后前列腺癌治疗功能评价问卷(FACT-P)评分较治疗前升高,差异有统计学意义(P＜0.05).Logistic回归分析显示,年龄＞60岁(OR=3.920,95％CI 1.216～12.631;P=0.023)、接受教育年限≤5 年(OR=3.967,95％CI 1.156～13.610;P=0.029)、血肌酐异常(OR=4.948,95％CI 1.204～20.331;P=0.027)、吸烟(OR=5.233,95％CI 1.281～21.376;P=0.022)、饮酒(OR=5.463,95％CI 1.774～16.828;P=0.003)、糖尿病(OR=5.669,95％CI 1.157～27.787;P=0.033)、高血压(OR=4.874,95％CI 1.426～16.658;P=0.012)、抑郁(OR=4.968,95％CI 1.710～14.429;P=0.003)、睾酮≤ 10 nmol/L(OR=5.964,95％CI 1.350～15.458;P=0.015)、肿瘤转移(OR=3.939,95％CI 1.416～10.959;P=0.009)及家庭人均收入 ≤2000 元(OR=3.626,95％CI 1.200～10.951;P=0.023)是前列腺癌患者生活质量的影响因素.结论 年龄＞60岁、接受教育年限≤5年、血肌酐异常、吸烟、饮酒、糖尿病、高血压、抑郁、睾酮≤10nmol/L、肿瘤转移及家庭人均收入≤2000元是新疆维吾尔自治区前列腺癌患者生活质量的影响因素,临床需对上述因素进行针对性干预,促进术后恢复.
Abstract
Objective To explore the changes in quality of life(QOL)after radical prostatectomy in patients with prostate cancer and influencing factors in Xinjiang Uygur Autonomous Region.Methods Clinical data of 240 patients with prostate cancer who underwent radical surgery in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2021 to December 2022 were collected and retrospectively analyzed.According to their score of QOL,they were divided into good QOL group(n=85)and poor QOL group(n=155).SPSS statistics 20.0 was used to perform the statistical analysis.Student's t test or Chi-square test was employed for inter-group comparison depending on data type.Logistic regression analysis was applied to analyze the factors influencing the QOL in patients undergoing radical prostatectomy due to prostate cancer.Results The functional assessment of cancer therapy-prostate(FACT-P)score was increased in the prostate cancer patients after surgical treatment(P＜0.05).Logistic regression analysis showed that age＞60 years(OR=3.920,95％CI 1.216-12.631;P=0.023),education duration ≤5 years(OR=3.967,95％CI 1.156-13.610;P=0.029),abnormal creatinine level(OR=4.948,95％CI 1.204-20.331;P=0.027),smoking(OR=5.233,95％CI 1.281-21.376;P=0.022),alcohol drinking(OR=5.463,95％CI 1.774-16.828;P=0.003),diabetes mellitus(OR=5.669,95％CI 1.157-27.787;P=0.033),hypertension(OR=4.874,95％CI 1.426-16.658;P=0.012),depression(OR=4.968,95％CI 1.710-14.429;P=0.003),testosterone ≤ 10 nmol/L(OR=5.964,95％CI 1.350-15.458;P=0.015),tumor metastasis(OR=3.939,95％CI 1.416-10.959;P=0.009),and per capita family income≤2 000 Yuan(OR=3.626,95％CI 1.200-10.951;P=0.023)were influencing factors for QOL in patients with prostate cancer.Conclusion Age＞60 years,education duration ≤ 5 years,abnormal creatinine level,smoking,alcohol drinking,diabetes mellitus,hypertension,depression,testosterone ≤10 nmol/L,tumor metastasis,and per capita family income ≤2 000 Yuan are influencing factors for poor QOL in prostate cancer patients after radical prostatectomy in Xinjiang Uygur Autonomous Region.Therefore,clinical interventions targeting these factors should be implemented to promote post-operative recovery.
基金项目
新疆维吾尔自治区自然科学基金杰出青年科学基金(2022D01E84)
维普
万方数据