中华老年多器官疾病杂志2024,Vol.23Issue(3) :225-228.DOI:10.11915/j.issn.1671-5403.2024.03.048

冠状动脉粥样硬化性心脏病炎症机制及抗炎治疗研究进展

Research progress in inflammation-related mechanism and anti-inflammation therapy for coronary artery disease

朱绍宁 胡舜英
中华老年多器官疾病杂志2024,Vol.23Issue(3) :225-228.DOI:10.11915/j.issn.1671-5403.2024.03.048

冠状动脉粥样硬化性心脏病炎症机制及抗炎治疗研究进展

Research progress in inflammation-related mechanism and anti-inflammation therapy for coronary artery disease

朱绍宁 1胡舜英1
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作者信息

  • 1. 中国人民解放军总医院第六医学中心心血管病医学部,北京 100853
  • 折叠

摘要

冠状动脉粥样硬化性心脏病(CAD)是人类死亡的主要原因之一,其发病机制是由于冠状动脉血管发生动脉粥样硬化病变而引起血管腔狭窄或阻塞,造成心肌缺血、缺氧或坏死而导致的心脏病.在动脉粥样硬化的发生发展过程中,炎症起着至关重要的作用.炎症是冠心病发病机制研究中的一大热点.抗炎治疗药物能否对炎症进行靶向干预并对冠心病患者的预后产生积极的影响日益引起人们的重视.本文扼要综述了介导冠心病发病的关键炎症分子及抗炎药物治疗冠心病的研究进展.

Abstract

Coronary artery disease(CAD)is one of the leading causes of human mortality,and is a common heart condition that involves atherosclerotic plaque formation in the vessel lumen,which then leads to coronary stenosis or occlusion of the vascular lumen,resulting in myocardial ischemia,hypoxia,or necrosis.Inflammation plays a vital role in mediating the occurrence and development of atherosclerosis.Inflammation has been a research hotspot in the study of the pathogenesis of CAD.Increasingly attention has been attracted to whether anti-inflammatory drugs can carry out targeted intervention on inflammation and positively impact the prognosis of CAD patients.In this article,we briefly review the essential inflammatory molecules in the pathogenesis and the research progress of anti-inflammatory drugs for the condition.

关键词

冠状动脉粥样硬化性心脏病/炎症/抗炎治疗

Key words

coronary artery disease/inflammation/anti-inflammatory therapy

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基金项目

国家自然科学基金(82173450)

出版年

2024
中华老年多器官疾病杂志
中国人民解放军总医院老年心血管病研究所

中华老年多器官疾病杂志

CSTPCD
影响因子:0.728
ISSN:1671-5403
参考文献量36
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