Coagulation dysfunction and its effect on prognosis in patients with coronavirus disease 2019 pneumonia
Objective To analyze the characteristics of plasma D-dimer,fibrin degradation products(FDPs)and other coagulation indices in patients with coronavirus disease 2019(COVID-19)pneumonia and explore their predictive value for patient's condition.Methods A total of 100 patients with COVID-19 pneumonia admitted to our hospital from December 7,2022 to January 28,2023 were enrolled and then divided into mild(n=29),moderate(n=40),and severe/critical infection(n=31)groups.Their plasma D-dimer,FDPs and other coagulation indices were recorded,and the characteristics of coagulation indices were analyzed in the three groups.SPSS statistics 27.0 was used for statistical analysis.LSD-t test,Fisher exact test,Kruskal-Wallis test,χ2 test or Bonferroni calibration test were employed for intergroup comparison depending on data type.Receiver operating characteristic(ROC)curve was plotted to evaluate the diagnostic value of FDPs,D-dimer,age,and their combination in predicting mortality in the COVID-19 infected patients.Results Larger proportions of older age and comorbidities and higher mortality were observed in the severe/critical groups than the mild and moderate groups(P<0.05).Plasma FDPs level in the moderate group and plasma FDPs and D-dimer levels in the severe/critical group were significantly higher than those in the mild group(P<0.05).The area under the curve(AUC)of FDPs,D-dimer,age,combined FDPs and D-dimer,and combination of FDPs,D-dimer and age in predicting mortality in the COVID-19 infected patients was 0.785(95%CI 0.645-0.926;P<0.01),0.811(95%CI 0.691-0.03;P<0.01),0.725(95%CI 0.558-0.891;P<0.05),0.766(95%CI 0.581-0.951;P<0.05)and 0.875(95%CI 0.789-0.962;P<0.01),respectively,and the sensitivity was 90.9%,100.0%,72.7%,81.8%and 100.0%,and the specificity was 61.8%,50.6%,78.7%,71.9%and 62.9%,respec-tively.Conclusion Plasma D-dimer and FDPs levels are significantly increased in COVID-19 patients.The two indicators combined with advanced age have an important predictive value for the severity and poor prognosis of COVID-19.
NETL
NSTL
万方数据
维普
